To identify the in vivo interaction among miR‐15b, USP7 and KDM5B, we established models of osteoporosis mice and treated them with injection of miR‐15b agomir + oe‐NC, agomir‐NC + oe‐NC and miR‐15b agomir + oe‐KDM6B. Here, KDM5B is linked to osteoporosis.