Western blot analysis showed reduced protein levels of Runx2, osterix, LC3II/I and elevated P62 protein level in osteoporosis mice injected with miR‐15b antagomir, while the results were opposite in osteoporosis mice injected with miR‐15b antagomir and expression vectors containing KDM6B (P < .05) (Figure 6F). The gene discussed is KDM6B; the disease is osteoporosis.