MiR-21 is involved in the fine-tuning of von Hippel Lindau tumor suppressor (VHL) expression, and VHL tumor suppressor gene is involved in the regulation of hypoxia response through the regulation of hyperxia inducible factors (HIFs) [7] VHL-HIF signaling pathways play an important role in the pathogenesis of CCRCC. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.