Additionally, association analysis of CMTM6 mRNA levels with Wnt target genes (TCF4, LEF1, CD-44, MMP14, ENC1, ID2, PPARA, and JAG1) from the cancer genome atlas HNSCC cohort using GEPIA showed a positive correlation (r > 0.2) (Supplemental Figure 9). Here, LEF1 is linked to head and neck squamous cell carcinoma.