BRCA1 and breast cancer: One study has demonstrated the prevalence of BRCA1 or BRCA2 mutation in 21.5% of 349 unrelated individuals in Brazil with personal or familial high risk for HBOC syndrome.31 Integrating genetic cancer risk assessment in primary care with a genetic counselor is a potential opportunity for systematically screening high-risk families and individuals,32,33 which seems to be a rational measure for populations with high breast cancer incidence and prevalence.