Although the highly abundant Rad51 proteins arising from efficient transcription or translation have been correlated with developmental or pathological conditions, such as respectively in mouse embryonic stem cells or irradiation-resistant tumor cells (Raderschall et al. 2002; Tichy et al. 2012), our understanding of how cells secure Rad51 protein stability in various physiological environments is limited (Ahmed et al. 2018; Ning et al. 2017; Woo et al. 2020). The gene discussed is RAD51; the disease is neoplasm.