LAMP2 and crescentic glomerulonephritis: Lysosomes have reached fame in nephrology with the discovery that antibodies to a bacterial antigen can cross-react to a previously characterized antineutrophil cytoplasmic antigen (ANCA), namely LAMP2 (Kain et al. 1995) to cause pauci-immune necrotizing and crescentic glomerulonephritis (Kain et al. 2008).