For example, deregulation of alternative splicing of the gene STOX1, involved in preeclampsia and Alzheimer's disease (Dijk et al. 2005,2010) induces a disequilibrium of its two isoforms and increases the risk of disease (Vaiman and Miralles 2016; Ducat 2020). The gene discussed is STOX1; the disease is Alzheimer disease.