LncRNA SOX2‐OT appears to have a relevant role in several malignant diseases including osteosarcoma [16], ovarian cancer [17], gastric cancer [18], hepatocellular carcinoma [19], cholangiocarcinoma [14], esophageal squamous cell carcinomas [20], multiple myeloma [21], bladder cancer [15], and lung cancer [22]. The gene discussed is SOX2; the disease is esophageal squamous cell carcinoma.