Furthermore, our results suggest that LncRNA SOX2‐OT modulates the expression of the SOX2‐OT/SOX2/GLI‐1 trinomial axis, promoting changes in the histone code H3K4me3/H3K27Ac/H3K9me3/H3K27me3 at gene promoter sequences in lung cancer. Here, SOX2 is linked to lung carcinoma.