Altered processing of lipid species within skeletal muscle is often observed during obesity, T2DM, and other metabolic diseases with disrupted processing of species including diacylglycerols (DAGs) and ceramides associated with defects in the insulin signaling pathway (Coen & Goodpaster, 2012; Goodpaster & Wolf, 2004). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.