SLC2A4 and metabolic disease: In the case of cPLA2s, it is plausible that cPLA2α contribute to metabolic diseases because of its role in negatively regulating skeletal muscle growth (Haq et al., 2003; Park & Yoon, 2013) and cPLA2ε may regulate skeletal muscle GLUT4 translocation due to its role in membrane trafficking observed in HeLa cells (Antonescu et al., 2008; Capestrano et al., 2014), putatively leading to decreased glucose uptake.