While non‐cytosolic PLA2s have been extensively studied for their role in generating lipid mediators, the sPLA2s is the largest group and its most relevant members associated with metabolic diseases are group V (sPLA2‐V) and group IIE (sPA2‐IIE) (Sato et al., 2016); expressed highly in mouse white adipose tissue after high‐fat‐diet (HFD) (Sato et al., 2014). This evidence concerns the gene PLA2G2A and Other metabolic disease.