Importantly, several of these RBPs are implicated in familial neurodegeneration, including Fragile X Mental Retardation Protein 1 (FMR1, fragile X syndrome and associated disorders), Ataxin 2 (ATXN2, spinocerebellar ataxia 2, late‐onset PD), Fused in Sarcoma (FUS), and TAR DNA binding protein (TARDBP/TDP43) (amyotrophic lateral sclerosis, frontotemporal dementia).63, 64, 65, 66, 67, 68, 69, 70, 71, 72. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.