PIK3CA and cancer: In UC, the pathways mainly regulated by Caulis Sargentodoxae were Pathways in cancer, Proteoglycans in cancer, Endocrine resistance, Prostate cancer, AGE-RAGE signaling pathway in diabetic complications, HIF-1 signaling pathway, MicroRNAs in cancer, Fluid shear stress and atherosclerosis, PI3K-Akt signaling pathway and EGFR tyrosine kinase inhibitor resistance (Table 4).