ARC protein functions as anti-apoptotic factor and many studies conducted on ARCconcluded that it is a strong independent adverse prognostic marker in AML.Moreover, ARC was found to augment resistance to chemotherapeutic agents in AML andthe decrease in ARC levels sensitize AML cells to chemotherapy since ARC increaseschemokine CCL2, CCL4, and CXCL12 expression in mesenchymal stromal cells (MSC) andfacilitates leukemia-microenvironment interactions (Carter et al., 2016). This evidence concerns the gene CXCL12 and leukemia.