In contrast, PAI-1 was markedly increased in EMBs of subjects with high-grade DCMi (Fig. 1; 15.5 ± 0.4%, p ≤ 0.001), demonstrating a close connection between PAI-1 expression and the extent of inflammation in dilated cardiomyopathies. The gene discussed is SERPINE1; the disease is dilated cardiomyopathy.