ACTA1 and familial dilated cardiomyopathy: Supportingly, immunohistochemical staining of EMBs for activated myofibroblasts revealed a decreased prevalence of α-SMA+ cells in DCMi-high patients when compared to DCM and DCMi-low subjects (Fig. 2c, d; 32.2 ± 3.1 cells/mm2 vs. 63.8 ± 8.2 cells/mm2 and 70.1 ± 5.2 cells/mm2; p ≤ 0.05).