It is worth noting, that while examining additional mito-nuclear genes we found that the expression of MEF2D—a transcription factor that was shown to regulate both nDNA and mtDNA gene expression36, was higher in the HE subgroup (p < 1 × 10–6, Datasets II, FDR correction; p < 1 × 10–11, Dataset III, FDR correction), thus suggesting an attractive candidate regulator, which explains differences between the HE and LE subgroups. The gene discussed is MEF2D; the disease is hereditary elliptocytosis.