HMGB1 and cancer: While there are reports showing that the DAMP, HMGB1 is released by ferroptotic cells [36] and this factor might support ferroptosis as immunogenic in nature similarly to necroptosis, additional investigation is warranted to understand the relevance of ferroptotic cell clearance vis-a-vis clearance of apoptotic and necrotic cells in the balance between proinflammatory and anti-inflammatory responses in normal physiology and pathophysiology in diseases including cancer.