PRL and retinal degeneration: In a recent study that analyzed the transcriptional changes in retina occurring at an advanced disease stage (≥ 50% photoreceptor loss) of two non-allelic canine forms of inherited retinal degeneration (rcd1/PDE6B mutation and xlpra2/RPGR mutation), we found that PRL was one of the top upregulated (50–150 fold) transcripts in both diseases33.