Results (Fig. 10C,D) showed that the specific cleavage forms of active caspase 7 and caspase 9 were detected in cells infected with ZIKV on 1 day and 2 day post infection, implying the induction of ER stress mediated intrinsic apoptosis in response to ZIKV infection. The gene discussed is CASP9; the disease is Zika virus infectious disease.