This is in agreement with Kiser et al., who found an association between seven genes linked to the NF-κβ pathway (DUSP10, IKBKB, NR4A1, PRKCA, SLC2A5, TGFB2, and PIK3R1) and MAP tissue infection in two Holstein populations using gene set enrichment analysis-SNP (GSEA-SNP)16. The gene discussed is PIK3R1; the disease is infection.