TLR7 and systemic lupus erythematosus: It is known that TLR7, the receptor for ssRNAs including self RNA, plays an important role in modulating the immunopathogenesis of systemic autoimmune disorders, such as SLE.6,31 Autoantibodies to nuclear antigens play an essential role in the immunopathogenesis of SLE, a spectrum of systemic autoimmune disorders.