TLR7 and type 1 diabetes mellitus: MHC-I plays a critical role in T1D development, and the expression of both classical MHC-I and nonclassical MHC-I molecules is enhanced in the islets of patients with T1D37; conversely, MHC-I deficiency is sufficient to prevent β-cell destruction by autoreactive CD8+ T cells and T1D development in NOD mice.38 Interestingly, we found that Tlr7−/− NOD B cells could inhibit the proliferation of cytotoxic CD8+ T cells.