The results from the RELATE (Ranibizumab Dose Comparison and the Role of Laser in Retinal Vein Occlusions; NCT01003106) and the WAVE (Wide-field Angiography Guided Targeted Retinal Photocoagulation Combined with Anti-VEGF Intravitreal Injections for the Treatment of Ischemic Retinal Vein Occlusion; NCT01710839) trials also highlighted that peripheral photocoagulation does not appreciably affect the treatment burden or visual outcomes in RVO patients14,19,20. The gene discussed is VEGFA; the disease is retinal vein occlusion.