The most commonly mutated genes in 49 primary lesions were TP53, NF1, LRP2, and NTRK3, while in 10 metastatic lesions, the most commonly mutated genes were TP53, NF1, TERT, NOTCH3, and PRKCI. The mutation frequency of LRP2 and NTRK3 in metastatic tumors was higher than those in primary tumors (2% vs. 20%, P = 0.072, for both). This evidence concerns the gene NOTCH3 and metastatic neoplasm.