Although the mutations of BRCA1 and BRCA2 are the most common germline mutations in ovarian cancer, the mutational frequency of BRCA1 is significantly higher in Chinese than in Western (P = 0.0001), while the mutation frequency of BRCA2 is similar between them (P = 0.78) (Fig. 3B). Here, BRCA1 is linked to ovarian carcinoma.