PEG3, ZNF365, HERC1, FBXW7, TERF2IP, STAT4, NLK, RBFOX2, CDK5, POLR2K, PSMD12 were gained in the AD samples, whereas BZW2, RNF6, ZBTB11, SORBS3, TRIM56, MORF4L1, CNOT7, RBCK1, SMYD3, RAN, KLHL12, ZC3H15, and EID1 were lost in the AD samples. The gene discussed is ZC3H15; the disease is Alzheimer disease.