Cases in studies of aggressive prostate cancer were men with high grade (Gleason score ≥ 7 or ≥ 8, 13 studies), higher stage (T2-3 or metastatic, 1 study), high volume (1 study), high risk ‘D’Amico’ classification (1 study), biochemical recurrence after prostatectomy (1 study) or a combination score (defined by either high Gleason score, advanced TNM stage, high PSA level or fatal disease, 3 studies). The gene discussed is KLK3; the disease is Familial prostate cancer.