Of note, plasma ADM levels are elevated in patients with hypertension, congestive heart failure or myocardial infarction6,7, renal diseases8, diabetes mellitus9, the acute phase of stroke10, septic shock11, arterial stiffness assessed by PWV12, and the magnitude of the elevation is in proportion to the severity of the disease involving vascular damage. This evidence concerns the gene ADM and hypertensive disorder.