FMR1 and Intellectual disability: Our results indicate that germinal genes shown enrichment in several gene-sets (germinal genes = 228, germinal DNMs = 236): FMRP target genes (p value = 0.003), known intellectual disability genes (p value = 0.0073), LoF intolerant genes (p value = 0.002), SFARI genes (p value = 1 × 10–7) and genes involved in chromatin organization (p value = 0.00018) (Table 3).