In addition, the germinal gene list (germinal genes = 1972, germinal DNMs = 2270) showed enrichment for FMRP target genes (p value = 1 × 10–6), known intellectual disability genes (p value = 1 × 10–6) and synaptic genes (p value = 4 × 10–6) (Table 4, Fig. 2). Here, FMR1 is linked to Intellectual disability.