We have shown that only diets containing high ratios of n-3:n-6 (10:1 and 25:1) inhibited carcinogenesis, inhibited NF-κB ,and activated PPARɣ in mammary adenocarcinomas induced by N-methyl-N-nitrosourea (MNU) in the rat7. The gene discussed is NFKB1; the disease is breast adenocarcinoma.