Of the investigated cells (CD4+ and CD8+ T lymphocytes, Tregs, NK cells, neutrophils, classical/intermediate/non-classical monocytes and CLL cells) and their activation markers, the best clustering of patients was observed using CLL counts and HLA-DR expression on CLL cells and classical, intermediate and non-classical monocyte subsets. This evidence concerns the gene CD8A and B-cell chronic lymphocytic leukemia.