Similar results were obtained when analysing newly diagnosed treatment-naïve patients, subdivided according to the low (< 4 points) vs high (≥ 4 points) CLL-IPI prognostic score (AUC = 0.805, data not shown), which includes age, Binet stage, level of serum β2-microglobulin, IgHV status, and TP53 status27. Here, HLA-G is linked to B-cell chronic lymphocytic leukemia.