Findings from this work do not provide a conclusive and mechanistic explanation for the coagulopathies in A. vasorum infections but provide a few leads to shape future research on the role of FXIII-B (for its roles in fibrin stabilization), MASP-1 and -2 (for their thrombin-like activity and as regulators of fibrin clot formation and stabilization), ADAMTS13 (involved in von Willebrand factor cleavage), and HRG (as a regulator of coagulation and fibrinolysis) in particular. Here, VWF is linked to blood coagulation disease.