As shown in Fig. 3C–E, whereas GEM treatment exhibited a profound inhibitory effect on the growth of control tumors (tumor weight: 0.30 ± 0.07 g vs. 0.07 ± 0.05 g, P < 0.001), it failed to achieve comparable therapeutic efficacy for ABCA8-overexpressing tumors (tumor weight: 0.36 ± 0.12 g vs. 0.20 ± 0.07 g, P < 0.05). Here, ABCA8 is linked to neoplasm.