Enriched pathways involved (A) muscarinic acetylcholine receptor types 1 and 3 signaling (mAChR1/3; 27 genes, false discovery rate FDR = 0.017), (B) Alzheimer disease-amyloid secretase (30 genes, FDR = 0.034), (C) heterotrimeric G-protein-coupled receptor Gq/Go α signaling (GPCRq/o-α; 53 genes, FDR = 0.04), and (D) histamine H1R mediated signaling (H1R; 27 genes, FDR = 0.039). This evidence concerns the gene HRH1 and early-onset autosomal dominant Alzheimer disease.