For example, lncRNA PCAT1 was found to promote the metastasis of endometrial carcinoma via the downregulation of E-cadherin by EZH2-mediated methylation12; Sun et al. found that EZH2 could epigenetically suppress the lncRNA SPRY4-IT1, which thus facilitated the proliferation and metastasis of non-small cell lung cancer13. The gene discussed is EZH2; the disease is endometrial carcinoma.