This mechanism of SNHG6 was first reported in chondrosarcoma and was quite different from the general function of SNHG6 in early studies, since our results evinced that lncRNA could work as one epigenetic modulator to mediate the association between histone methyltransferase and target genes; however, this novel function required further investigation in other tumor cells. The gene discussed is SNHG6; the disease is chondrosarcoma.