To explore the function of SNHG6 in the progression of chondrosarcoma, we then knocked down SNHG6 by shRNA in both HCS2/8 and SW1353 cells and assessed the influence of SNHG6 knockdown on the proliferation, migration, tumorigenesis, and metastasis of chondrosarcoma cells. Here, SNHG6 is linked to chondrosarcoma.