CASP3 and osteosarcoma: In osteosarcoma (OS), Xin Zhu and his colleagues found that knockdown of SNHG6 in OS could potently inhibit OS cell growth and proliferation, repress cell invasion, and induce cell apoptosis; mechanistic study revealed that SNHG6 sponged miR-26a-5p and thereby enhanced the expression of Unc-51-like autophagy activating kinase 1, leading to upregulated apoptosis by caspase 3 and autophagy by activating transcription factor 323.