Recently, Shaoxun Xiang et al found that c-Myc could repress the expression of lncRNA IDH1-AS1 and sustained the activation of Warburg effect by hypoxia-inducible factor 1α under normoxic conditions in cancer cells28; Hui Wang et al. reported that STAT3 could specifically bind to the promoter of HOXD-AS1 and activate the transcription of lncRNA HOXD-AS1, which was associated with the metastasis and invasion of HCC29. The gene discussed is IDH1; the disease is cancer.