EZH2 and chondrosarcoma: Another interesting finding was the positive feedback loop for SP1/SNHG6/EZH2/KLF6 axis, which severely repressed the expression and function of KLF6, one central regulator for the progression of chondrosarcoma; at the same time, the levels of SP1 and SNHG6 were further elevated due to the attenuation of KLF6.