Stimulation of the CAR-T cells with clonal cell lines expressing graded amounts of CXCR5 demonstrated a sufficiently high avidity for CXCR5 levels found on primary B-NHLs and CXCR5-positive lymphocytes (Supplementary Fig. 5b) thereby making the CXCR5 CAR suitable for lymphoma targeting. The gene discussed is CXCR5; the disease is lymphoma.