CXCR5 and leukemia: The mCXCR5 CAR-T cells reacted specifically against primary murine CXCR5+/+Eμ-Tcl1 leukemia cells, splenic B220+ B cells, and CXCR5-transduced BW5147 cells as indicated by a high release of mIFNγ and mIL2 (Fig. 8c), whereas CXCR5−/−Eμ-Tcl1 cells and non-transduced BW5147 cells failed to activate mCXCR5 CAR-T cells.