The exhaustion markers PD-1, LAG-3, and TIM-3 were not differentially upregulated over 13 days on BM or splenic localized CD4+ and CD8+ CXCR5 CAR-T compared to SP6 CAR-T cells (Supplementary Fig. 11f–h), thus exhaustion seems to be unlikely involved in loss of tumor control. The gene discussed is CD8A; the disease is neoplasm.