Following confirmation by PCR and Sanger sequencing that blasts from mice with AML driven by Trib2 expressed wild-type p53 (data not shown), we first confirmed superior eradication of the murine leukemic cells by the drug combination compared to the two single drugs in vitro (Fig. 2a–c), recapitulating the effect in human cells. Here, TRIB2 is linked to acute myeloid leukemia.