CNR1 and familial pancreatic carcinoma: Arachidonoylcyclopropylamide (ACPA) is a synthetic CB1 agonist28,29 stimulating free oxygen radical-dependent autophagy by 5’-adenosine monophosphate-activated protein kinase (AMPK) activation in Panc1 pancreatic cancer cells30 and has antiproliferative effect on Panc1 cells31–33 while its impact on lung cancers remains unknown.