Mutational signature analysis on our WGS data revealed a predominance of COSMIC SBS7v2 in nine of the conjunctival melanomas, whereas one conjunctival melanoma and the other eight mucosal melanomas were dominated by the SBS1v2 (age-related), SBS5v2 (ubiquitous), and SBS3v2 (BRCA1, BRCA2, and PALB2-associated) (Fig. 1a, b). Here, PALB2 is linked to malignant conjunctival melanoma.