ANXA5 and melanoma: Indeed, when cells enter apoptosis, a flip-flop into the plasma membrane takes place and phosphatidylserines, which are normally inside the cells, are exposed to the extracellular medium and can link with annexin V. After CRO15 stimulation, we observed a large increase in melanoma cells stained with annexin V. We also studied the presence of caspase 3 active cells after CRO15 stimulation.