When Wnt glycoprotein ligands binding to Frizzled transmembrane receptors and LDL receptor-related protein 6 (LRP6), β-catenin is stabilized and translocated to the nucleus where it forms a complex with lymphoid enhancer factor (LEF1), then activates the transactivation of Wnt target genes such as Myc, CyclinD1, and Axin2. The dysregulation of Wnt signaling can lead to the onset and development of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington22. Here, LRP6 is linked to Parkinsonism.