The carboxy-terminus of HSC70-interacting protein (CHIP), encoded by the STUB1 gene, is an E3 ubiquitin ligase containing a three tetratricopeptide repeat domains, and a U-box domain displaying E3 ubiquitination ligase activity which participates in many vital processes to modulate protein degradation, cell proliferation, metastasis, and tumor progression1. Here, STUB1 is linked to neoplasm.