To test whether targeting the BCL-XL can enhance the DHT’s suppressive effect on PCa tumor growth in a xenograft model in vivo, we generated cells with stable expression of sh-BCL-XL, as well as vector control cells and orthotopically implanted these cells in the anterior of prostates with 4 groups, 1: pLKO + EtOH; 2: pLKO + Testosterone; 3: sh-BCL-XL + EtOH; 4: sh-BCL-XL + Testosterone (Fig. 6A). Here, BCL2L1 is linked to posterior cortical atrophy.