In addition, the presence GFAP-IgG seropositivity in autoimmune GFAP astrocytopathy, an autoimmune disease of the nervous system50 and the increased risk of AD in individuals with autoimmune diseases51, along with our observations of increased plasma GFAP in individuals at risk of AD, warrant further investigation into the link between AD and autoimmune disorders, and the investigation of possible mechanisms associated with this link. This evidence concerns the gene GFAP and Alzheimer disease.