Third, m6A modification of RNAs likely promotes tumor progressions induced by ALKBH5 inhibition; specifically, m6A methylation of pre-miR-181b-1 in the nucleus by the m6A mechanism causes considerable downregulation of mature miR-181b-5p in the cytoplasm, which may account at least partially for the tumor growth. Here, ALKBH5 is linked to neoplasm.