To further determine the biological function of CREBBP and EP300 mutations in DLBCL, DB, SUDHL4, and LY10 cells were engineered to express a fragment of the CREBBP (amino acid 960-1630, containing BRD and HAT domain for the wild-type; amino acid 960-1392, containing BRD and partial HAT domain for CREBBPR1392*) or EP300 (amino acid 1267-1670, containing HAT domain for the wild-type; amino acid 1267-1670, containing HAT domain for EP300H1377R) protein. Here, CREBBP is linked to diffuse large B-cell lymphoma.