TAMs contribute to tumor progression by providing a barrier against anti-tumor T-cell immunity and help to predict the prognosis of DLBCL patients.21,38 To our knowledge, this is the first report on the impact of CREBBP and EP300 mutation on TAMs, suggesting an alternative mechanism of epigenetic alterations on tumor microenvironment in DLBCL. The gene discussed is CREBBP; the disease is neoplasm.