CCL2 and CSF1 are essential in macrophage recruitment and polarization in the tumor microenvironment.19 As detected by quantitative RT-PCR (Fig. 6f) and western blot (Fig. 6g), CREBBP mutations and CREBBP knockdown resulted in significantly increased expression of CCL2 and CSF1 at transcriptional and protein levels in DB cells. Here, CREBBP is linked to neoplasm.