The perturbation of the epigenome is a hallmark of B-cell lymphoma.27,28 In the present large cohort of DLBCL patients, histone acetyltransferases CREBBP and EP300 were both highly recurrent and significantly associated with poor prognosis, providing clinical evidence that alterations in histone acetylation are important tumorigenic events in DLBCL. Here, EP300 is linked to B-cell non-Hodgkin lymphoma.