Of particular interest to us was that ST intoxication enhanced production of the IL-1 family member IL-33, an alarmin released upon epithelial cell damage (25) and implicated in TH2-mediated inflammation, including antihelminth immunity (37), epithelial repair (38), allergic asthma (39), goblet cell hyperplasia (40), and inflammatory bowel disease (41). This evidence concerns the gene IL1B and allergic asthma.