Men seeking PSA screening in general practice may not be uncommon, which gives a mandate for a deep awareness among clinicians of the benefits and harms of PSA screening, which is sometimes limited.19,31,32 Predictors of screening uptake may be useful for the design of future screening strategies, and the data presented here may help give some context to findings of other studies regarding trends in prostate cancer incidence, stage at diagnosis, treatments, and mortality in the UK. This evidence concerns the gene KLK3 and Familial prostate cancer.