One of the two above patients with HLA-B, HLA-C, and OR7E24 mutations and high overall tumor mutational burden received treatment with temozolomide and re-irradiation, potentially leading to mutagenesis; however, when comparing patients with higher or lower than the cohort average mutational load at autopsy, there was no significant difference in the proportion who underwent prior alkylating chemotherapy and/or re-irradiation. This evidence concerns the gene HLA-C and neoplasm.