The induction kinetics of DUSP6 was slightly different among the three cell types: in Vero and DF-1 cells, DUSP6 protein was gradually induced over infection time from 12 to 20 hpi; however, in H1299 cells, the induction of DUSP6 was much earlier than the two other cell lines, as early as 4 hpi, which was due to the faster replication of virus in H1299 cells than the other two cell lines (Additional file 3). The gene discussed is DUSP6; the disease is infection.