In terms of treatment, while METTL3-silenced GSCs and pancreatic cancer cells showed enhanced sensitivity to irradiation [160, 161], METTL3-depleted cells induced NSCLC and pancreatic cancer chemotherapeutic drug resistance to gemcitabine, 5-fluorouracil, cisplatin, etc. [161, 162] (Fig. 4). The gene discussed is METTL3; the disease is familial pancreatic carcinoma.