METTL3 and hereditary clear cell renal cell carcinoma: Although the effects of METTL3 are mechanistically similar to those in GC and LCA in terms of the EMT and PI3K-Akt-mTOR pathways, in renal cell carcinoma (RCC), knocking down METTL3 significantly promoted cell proliferation, migration and invasion [141] (Fig. 4).