However, the association between GFR and dementia was not modified by age (≥ 70 or < 70 years old), baseline diabetes, hypertension, APOE-ε4, serum creatinine (≥ 0.85 or < 0.85 mg/dl), and BMI (≥ 24 or < 24 kg/m2) (Pinteraction > 0.05 for all). Here, APOE is linked to diabetes mellitus.