These potential target genes were placed in the Metascape for KEGG pathway analysis, and 20 significant pathways that may be regulated by ginger in the treatment of colon cancer were identified, including pathways in cancer, endocrine resistance, hepatitis B, PI3K-Akt signaling pathway, and EGFR tyrosine kinase inhibitor resistance. Here, EGFR is linked to malignant colon neoplasm.