ZDHHC8 and 22q11.2 deletion syndrome: A particularly interesting observation of the study was that expression of the palmitoylated form of Cdc42 restored long-term spine stabilization in hippocampal slices from mice with 22q11.2 deletion syndrome, similar to another study on mice with that syndrome showing that palmitoylation of Cdc42 by ZDHHC8 was capable of promoting axon growth and branching [77, 78].