Several signaling pathways that regulate vasculogenesis and angiogenesis have been demonstrated to be associated with the pathogenesis of IH [7, 8] primarily including the vascular endothelial growth factor (VEGF) and VEGF receptor pathways, notch pathway, mammalian target of rapamycin pathway, β-adrenergic signaling pathway and angiopoietin and Tie2 signaling pathway [7] [8],. The gene discussed is VEGFA; the disease is isolated hemihyperplasia.